Oscillatory Shear Stress Induces Mitochondrial Superoxide Production: Implication of NADPH Oxidase and c-Jun NH(2)-Terminal Kinase Signaling

Fluid shear stress is intimately linked with vascular oxidative stress and atherosclerosis. We posited that atherogenic oscillatory shear stress (OSS) induced mitochondrial superoxide (mtO(2)(•−)) production via NADPH oxidase and c-Jun NH(2)-terminal kinase (JNK-1 and JNK-2) signaling. In bovine aor...

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Detalles Bibliográficos
Autores principales: Takabe, Wakako, Jen, Nelson, Ai, Lisong, Hamilton, Ryan, Wang, Sky, Holmes, Kristin, Dharbandi, Farhad, Khalsa, Bhavraj, Bressler, Steven, Barr, Mark L., Li, Rongsong, Hsiai, Tzung K.
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2011
Materias:
Forum Original Research Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3144427/
https://ncbi.nlm.nih.gov/pubmed/20919940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2010.3645
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