TCF7L2 Polymorphism, Weight Loss and Proinsulin∶Insulin Ratio in the Diabetes Prevention Program

AIMS: TCF7L2 variants have been associated with type 2 diabetes, body mass index (BMI), and deficits in proinsulin processing and insulin secretion. Here we sought to test whether these effects were apparent in high-risk individuals and modify treatment responses. METHODS: We examined the potential...

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Main Authors: McCaffery, Jeanne M., Jablonski, Kathleen A., Franks, Paul W., Dagogo-Jack, Sam, Wing, Rena R., Knowler, William C., Delahanty, Linda, Dabelea, Dana, Hamman, Richard, Shuldiner, Alan R., Florez, Jose C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3144193/
https://ncbi.nlm.nih.gov/pubmed/21814547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021518
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