Toll-like Receptor-mediated Inflammatory Signaling Reprograms Cardiac Energy Metabolism by Repressing Peroxisome Proliferator-activated Receptor γ Coactivator-1 (PGC-1) Signaling

BACKGROUND: Currently, there are no specific therapies available to treat cardiac dysfunction due to sepsis and other chronic inflammatory conditions. Activation of toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) is an early event in gram-negative bacterial sepsis, triggering a robust inflam...

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Detalhes bibliográficos
Main Authors: Schilling, Joel, Lai, Ling, Sambandam, Nandakumar, Dey, Courtney E., Leone, Teresa C., Kelly, Daniel P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3144030/
https://ncbi.nlm.nih.gov/pubmed/21558447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.110.959833
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