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Stimulation of Yeast Telomerase Activity by the Ever Shorter Telomere 3 (Est3) Subunit Is Dependent on Direct Interaction with the Catalytic Protein Est2

Telomerase is a multisubunit enzyme that maintains genome stability through its role in telomere replication. Although the Est3 protein is long recognized as an essential telomerase component, how it associates with and functions in the telomerase complex has remained enigmatic. Here we provide the...

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Autori principali: Talley, Jennell M., DeZwaan, Diane C., Maness, Leslie D., Freeman, Brian C., Friedman, Katherine L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143607/
https://ncbi.nlm.nih.gov/pubmed/21659533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.228635
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