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Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling
Mutations in Drosophila rumi result in a temperature-sensitive loss of Notch signaling. Rumi is a protein O-glucosyltransferase that adds glucose to EGF repeats with a C-X-S-X-P-C consensus sequence. Eighteen of the 36 EGF repeats in the Drosophila Notch receptor contain the consensus O-glucosylatio...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Company of Biologists
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3143569/ https://ncbi.nlm.nih.gov/pubmed/21771811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.068361 |
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