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Inferring Gene-Phenotype Associations via Global Protein Complex Network Propagation

BACKGROUND: Phenotypically similar diseases have been found to be caused by functionally related genes, suggesting a modular organization of the genetic landscape of human diseases that mirrors the modularity observed in biological interaction networks. Protein complexes, as molecular machines that...

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Detalhes bibliográficos
Main Authors: Yang, Peng, Li, Xiaoli, Wu, Min, Kwoh, Chee-Keong, Ng, See-Kiong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143124/
https://ncbi.nlm.nih.gov/pubmed/21799737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021502
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