Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury

The role of EGF in the evolution of renal lesions after injury is still controversial. To determine whether the EGF expression is beneficial or detrimental, we generated transgenic mice expressing a COOH-terminal–truncated EGF-R under the control of the kidney-specific type 1 γ-glutamyl transpeptida...

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Main Authors: Terzi, Fabiola, Burtin, Martine, Hekmati, Mehrak, Federici, Pierre, Grimber, Giselle, Briand, Pascale, Friedlander, Gérard
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2000
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC314303/
https://ncbi.nlm.nih.gov/pubmed/10903338
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