High-Throughput MALDI-TOF Discovery of Genomic Sequence Polymorphisms

We describe a comparative sequencing strategy that is based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) analyses of complete base-specific cleavage reactions of a target sequence. The target is converted to a DNA/RNA mosaic structure after PCR ampli...

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Bibliographic Details
Main Authors: Stanssens, Patrick, Zabeau, Marc, Meersseman, Geert, Remes, Gwen, Gansemans, Yannick, Storm, Niels, Hartmer, Ralf, Honisch, Christiane, Rodi, Charles P., Böcker, Sebastian, van den Boom, Dirk
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2004
Subjects:
Methods
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC314289/
https://ncbi.nlm.nih.gov/pubmed/14707174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.1692304
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