A region of the sulfonylurea receptor critical for a modulation of ATP-sensitive K(+) channels by G-protein βγ-subunits

To determine the interaction site(s) of ATP-sensitive K(+) (K(ATP)) channels for G-proteins, sulfonylurea receptor (SUR2A or SUR1) and pore-forming (Kir6.2) subunits were reconstituted in the mammalian cell line, COS-7. Intracellular application of the G-protein βγ2-subunits (G(βγ2)) caused a reduct...

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Main Authors: Wada, Yoshiyuki, Yamashita, Toshikazu, Imai, Kohbun, Miura, Reiko, Takao, Kyoichi, Nishi, Miyuki, Takeshima, Hiroshi, Asano, Tomiko, Morishita, Rika, Nishizawa, Kazuhisa, Kokubun, Shinichiro, Nukada, Toshihide
格式: Artigo
語言:Inglês
出版: Oxford University Press 2000
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC314227/
https://ncbi.nlm.nih.gov/pubmed/10990455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.18.4915
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