Progressive Erosion of β-Cell Function Precedes the Onset of Hyperglycemia in the NOD Mouse Model of Type 1 Diabetes

OBJECTIVE: A progressive decline in insulin responses to glucose was noted in individuals before the onset of type 1 diabetes. We determined whether such abnormalities occurred in prediabetic NOD mice—the prototypic model for human type 1 diabetes. RESEARCH DESIGN AND METHODS: Morning blood glucose...

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Main Authors: Ize-Ludlow, Diego, Lightfoot, Yaima L., Parker, Matthew, Xue, Song, Wasserfall, Clive, Haller, Michael J., Schatz, Desmond, Becker, Dorothy J., Atkinson, Mark A., Mathews, Clayton E.
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2011
Fag:
Islet Studies
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142079/
https://ncbi.nlm.nih.gov/pubmed/21659497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0373
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