High-Fat Diet–Induced Adipocyte Cell Death Occurs Through a Cyclophilin D Intrinsic Signaling Pathway Independent of Adipose Tissue Inflammation

OBJECTIVE: Previous studies have demonstrated that mice fed a high-fat diet (HFD) develop insulin resistance with proinflammatory macrophage infiltration into white adipose tissue. Concomitantly, adipocytes undergo programmed cell death with the loss of the adipocyte-specific lipid droplet protein p...

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Autors principals: Feng, Daorong, Tang, Yan, Kwon, Hyokjoon, Zong, Haihong, Hawkins, Meredith, Kitsis, Richard N., Pessin, Jeffrey E.
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2011
Matèries:
Immunology and Transplantation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142076/
https://ncbi.nlm.nih.gov/pubmed/21734017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1411
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