Decreased Cytochrome c Oxidase IV Expression Reduces Steroidogenesis

Steroidogenic acute regulatory protein facilitates the translocation of cholesterol to the inner mitochondrial membrane, thereby initiating steroidogenesis. At the inner mitochondrial membrane, cytochrome P450 side-chain cleavage enzyme converts cholesterol to pregnenolone, an oxidative process requ...

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Autori principali: Pawlak, Kevin J., Prasad, Manoj, McKenzie, Kevin A., Wiebe, John P., Gairola, C. Gary, Whittal, Randy M., Bose, Himangshu S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2011
Soggetti:
Endocrine and Diabetes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141905/
https://ncbi.nlm.nih.gov/pubmed/21558439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.182634
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