Nimesulide inhibits protein kinase C epsilon and substance P in sensory neurons – comparison with paracetamol

In this paper we describe new actions of nimesulide and paracetamol in cultured peripheral neurons isolated from rat dorsal root ganglia (DRG). Both drugs were able to decrease in a dose-dependent fashion the number of cultured DRG neurons showing translocation of protein kinase C epsilon (PKCɛ) cau...

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Detalhes bibliográficos
Main Authors: Vellani, Vittorio, Franchi, Silvia, Prandini, Massimiliano, Moretti, Sarah, Pavesi, Giorgia, Giacomoni, Chiara, Sacerdote, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2011
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141834/
https://ncbi.nlm.nih.gov/pubmed/21811393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JPR.S21931
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