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Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster

Poly(ADP-ribosyl)ation has been suggested to be involved in regulation of DNA repair, transcription, centrosome duplication, and chromosome stability. However, the regulation of degradation of poly(ADP-ribose) and its significance are not well understood. Here we report a loss-of-function mutant Dro...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Hanai, Shuji, Kanai, Masayuki, Ohashi, Sayaka, Okamoto, Keiji, Yamada, Mitsunori, Takahashi, Hitoshi, Miwa, Masanao
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314142/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14676324/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2237114100
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