Identification of a methylated oligoribonucleotide as a potent inhibitor of HIV-1 reverse transcription complex

Upon HIV-1 infection of a target cell, the viral reverse transcriptase (RT) copies the genomic RNA to synthesize the viral DNA. The genomic RNA is within the incoming HIV-1 core where it is coated by molecules of nucleocapsid (NC) protein that chaperones the reverse transcription process. Indeed, th...

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Bibliographic Details
Main Authors: Grigorov, Boyan, Bocquin, Anne, Gabus, Caroline, Avilov, Sergey, Mély, Yves, Agopian, Audrey, Divita, Gilles, Gottikh, Marina, Witvrouw, Myriam, Darlix, Jean-Luc
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141241/
https://ncbi.nlm.nih.gov/pubmed/21447560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr117
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