(13)C Metabolic Flux Analysis Identifies an Unusual Route for Pyruvate Dissimilation in Mycobacteria which Requires Isocitrate Lyase and Carbon Dioxide Fixation

Mycobacterium tuberculosis requires the enzyme isocitrate lyase (ICL) for growth and virulence in vivo. The demonstration that M. tuberculosis also requires ICL for survival during nutrient starvation and has a role during steady state growth in a glycerol limited chemostat indicates a function for...

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Detalhes bibliográficos
Main Authors: Beste, Dany J. V., Bonde, Bhushan, Hawkins, Nathaniel, Ward, Jane L., Beale, Michael H., Noack, Stephan, Nöh, Katharina, Kruger, Nicholas J., Ratcliffe, R. George, McFadden, Johnjoe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141028/
https://ncbi.nlm.nih.gov/pubmed/21814509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002091
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