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Evidence for a Prepore Stage in the Action of Clostridium perfringens Epsilon Toxin

Clostridium perfringens epsilon toxin (ETX) rapidly kills MDCK II cells at 37°C, but not 4°C. The current study shows that, in MDCK II cells, ETX binds and forms an oligomeric complex equally well at 37°C and 4°C but only forms a pore at 37°C. However, the complex formed in MDCK cells treated with E...

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Bibliografiske detaljer
Main Authors: Robertson, Susan L., Li, Jihong, Uzal, Francisco A., McClane, Bruce A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140917/
https://ncbi.nlm.nih.gov/pubmed/21814565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022053
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