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Human DNA ligase I efficiently seals nicks in nucleosomes
The access to DNA within nucleosomes is greatly restricted for most enzymes and trans-acting factors that bind DNA. We report here that human DNA ligase I, which carries out the final step of Okazaki fragment processing and of many DNA repair pathways, can access DNA that is wrapped about the surfac...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC314012/ https://ncbi.nlm.nih.gov/pubmed/11032816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.20.5492 |
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