B-Cell Gene Therapy for Tolerance Induction: Host but Not Donor B-Cell Derived IL-10 is Necessary for Tolerance

Genetically modified B cells are excellent tolerogenic antigen-presenting cells (APCs) in multiple models of autoimmunity. However, the mechanisms of action are still not completely understood. In our models, we generate antigen-specific tolerogenic B cells by transducing naïve or primed B cells wit...

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Hlavní autoři: Su, Yan, Zhang, Ai-Hong, Noben-Trauth, Nancy, Scott, David W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Research Foundation 2011
Témata:
Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139928/
https://ncbi.nlm.nih.gov/pubmed/21811487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2011.00154
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