Brain Creatine Elevation and NAA Reduction Indicates Neuronal Dysfunction in the Setting of Enhanced Glial Energy Metabolism in a Macaque Model of neuroAIDS

Proton magnetic resonance spectroscopy ((1)H MRS) has emerged as one of the most informative neuroimaging modalities for studying the effect of HIV infection in the brain, providing surrogate markers by which to assess disease progression and monitor treatment. Reductions in the level of N-Acetylasp...

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Main Authors: Ratai, Eva-Maria, Annamalai, Lakshmanan, Burdo, Tricia, Joo, Chan-Gyu, Bombardier, Jeffrey P., Fell, Robert, Hakimelahi, Reza, He, Julian, Lentz, Margaret R., Campbell, Jennifer, Curran, Elizabeth, Halpern, Elkan F., Masliah, Eliezer, Westmoreland, Susan. V., Williams, Kenneth C., González, R. Gilberto
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139817/
https://ncbi.nlm.nih.gov/pubmed/21381104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrm.22821
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