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Small molecule displacement of a cryptic degron causes conditional protein degradation
The ability to rapidly regulate the functions of specific proteins in living cells is a valuable tool for biological research. Here we describe a novel technique by which the degradation of a specific protein is induced by a small molecule. A protein of interest is fused to a Ligand-Induced Degradat...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3139708/ https://ncbi.nlm.nih.gov/pubmed/21725303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.598 |
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