Compound C Stimulates Heme Oxygenase-1 Gene Expression via the Nrf2-ARE Pathway to Preserve Human Endothelial Cell Survival

We recently identified adenosine monophosphate-activated protein kinase (AMPK) as a novel inducer of heme oxygenase-1 (HO-1) and surprisingly found that compound C (6-[4-(2-piperidin-1-yl-ethoxy)-phenyl]3-pyridin-4-yl-pyrazolo[1,5-a] pyrimidine), a cell-permeable inhibitor of AMPK, could also elevat...

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Bibliographic Details
Main Authors: Liu, Xiao-ming, Peyton, Kelly J., Shebib, Ahmad R., Wang, Hong, Durante, William
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138903/
https://ncbi.nlm.nih.gov/pubmed/21635873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2011.05.016
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