Notch gain of function in mouse periocular mesenchyme downregulates FoxL2 and impairs eyelid levator muscle formation, leading to congenital blepharophimosis

Notch signaling is pivotal for the morphogenesis and homeostasis of many tissues. We found that aberrant Notch activation in mouse neural-crest-derived periocular mesenchymal cells (POMCs), which contribute to the formation of corneal and eyelid stroma, results in blepharophimosis. Compound transgen...

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Autores principales: Zhang, Yujin, Kao, Winston W.-Y., Pelosi, Emanuele, Schlessinger, David, Liu, Chia-Yang
Formato: Artigo
Lenguaje:Inglês
Publicado: Company of Biologists 2011
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138700/
https://ncbi.nlm.nih.gov/pubmed/21730020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.085001
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