Resting Glutamate Levels and Rapid Glutamate Transients in the Prefrontal Cortex of the Flinders Sensitive Line Rat: A Genetic Rodent Model of Depression

Despite the numerous drugs targeting biogenic amines for major depressive disorder (depression), the search for novel therapeutics continues because of their poor response rates (∼30%) and slow onset of action (2–4 weeks). To better understand role of glutamate in depression, we used an enzyme-based...

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Autors principals: Hascup, Kevin N, Hascup, Erin R, Stephens, Michelle L, Glaser, Paul EA, Yoshitake, Takashi, Mathé, Aleksander A, Gerhardt, Greg A, Kehr, Jan
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138656/
https://ncbi.nlm.nih.gov/pubmed/21525860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.60
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