Side Chain-oxidized Oxysterols Regulate the Brain Renin-Angiotensin System through a Liver X Receptor-dependent Mechanism

Disturbances in cholesterol metabolism have been associated with hypertension and neurodegenerative disorders. Because cholesterol metabolism in the brain is efficiently separated from plasma cholesterol by the blood-brain barrier (BBB), it is an unsolved paradox how high blood cholesterol can cause...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Mateos, Laura, Ismail, Muhammad-Al-Mustafa, Gil-Bea, Francisco-Javier, Schüle, Rebecca, Schöls, Ludger, Heverin, Maura, Folkesson, Ronnie, Björkhem, Ingemar, Cedazo-Mínguez, Angel
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Lipids
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138324/
https://ncbi.nlm.nih.gov/pubmed/21628469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.236877
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