4-Hydroxyphenylpyruvate Dioxygenase Catalysis: IDENTIFICATION OF CATALYTIC RESIDUES AND PRODUCTION OF A HYDROXYLATED INTERMEDIATE SHARED WITH A STRUCTURALLY UNRELATED ENZYME

4-Hydroxyphenylpyruvate dioxygenase (HPPD) catalyzes the conversion of 4-hydroxyphenylpyruvate (HPP) into homogentisate. HPPD is the molecular target of very effective synthetic herbicides. HPPD inhibitors may also be useful in treating life-threatening tyrosinemia type I and are currently in trials...

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Autors principals: Raspail, Corinne, Graindorge, Matthieu, Moreau, Yohann, Crouzy, Serge, Lefèbvre, Bertrand, Robin, Adeline Y., Dumas, Renaud, Matringe, Michel
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138293/
https://ncbi.nlm.nih.gov/pubmed/21613226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.227595
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