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Molecular Mechanism of Selective Recruitment of Syk Kinases by the Membrane Antigen-Receptor Complex
ZAP-70 and Syk are essential tyrosine kinases in intracellular immunological signaling. Both contain an inhibitory SH2 domain tandem, which assembles onto the catalytic domain. Upon binding to doubly phosphorylated ITAM motifs on activated antigen receptors, the arrangement of the SH2 domains change...
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Main Authors: | , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3138262/ https://ncbi.nlm.nih.gov/pubmed/21602568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.223321 |
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