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Molecular Mechanism of Selective Recruitment of Syk Kinases by the Membrane Antigen-Receptor Complex

ZAP-70 and Syk are essential tyrosine kinases in intracellular immunological signaling. Both contain an inhibitory SH2 domain tandem, which assembles onto the catalytic domain. Upon binding to doubly phosphorylated ITAM motifs on activated antigen receptors, the arrangement of the SH2 domains change...

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Detalhes bibliográficos
Main Authors: Bond, Peter J., Faraldo-Gómez, José D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138262/
https://ncbi.nlm.nih.gov/pubmed/21602568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.223321
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