Targeted Deletion of Adipocytes by Apoptosis Leads to Adipose Tissue Recruitment of Alternatively Activated M2 Macrophages

Obesity is frequently associated with an infiltration of macrophages into adipose tissue. Adipocyte dysfunction causes a phenotypic switch of macrophages from an alternatively activated M2-like phenotype towards a proinflammatory M1 phenotype. The cross talk between adipocytes and infiltrating immun...

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Main Authors: Fischer-Posovszky, Pamela, Wang, Qiong A., Asterholm, Ingrid Wernstedt, Rutkowski, Joseph M., Scherer, Philipp E.
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2011
Fag:
Diabetes-Insulin-Glucagon-Gastrointestinal
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138241/
https://ncbi.nlm.nih.gov/pubmed/21693678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1031
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