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Tumorigenesis in mice carrying a truncating Brca1 mutation
We generated mouse mutants carrying in the Brca1 locus a modification (Brca1(tr)) that eliminates the C-terminal half of the protein product and obtained results indicating that, depending on genetic background, the missing BRCT and/or other domains are dispensable for survival, but essential for tu...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC313794/ https://ncbi.nlm.nih.gov/pubmed/11358863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.879201 |
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