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Inhibition of 3,4-methylenedioxymethamphetamine (MDMA) metabolism leads to marked decrease in 3,4-dihydroxymethamphetamine (HHMA) formation but no change in serotonin neurotoxicity: Implications for mechanisms of neurotoxicity
3,4-Methylenedioxymethamphetamine (MDMA)’s O-demethylenated metabolite, 3,4-dihydroxymethamphetamine (HHMA), has been hypothesized to serve as a precursor for the formation of toxic catechol thioether metabolites (e.g. 5-N-acetylcystein-S-yl-HHMA) that mediate 3,4-methylenedioxymethamphetamine (MDMA...
Tallennettuna:
| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2011
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3137686/ https://ncbi.nlm.nih.gov/pubmed/21360595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/syn.20925 |
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