A Novel Inactivated Intranasal Respiratory Syncytial Virus Vaccine Promotes Viral Clearance without Th2 Associated Vaccine-Enhanced Disease

BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of bronchiolitis and pneumonia in young children worldwide, and no vaccine is currently available. Inactivated RSV vaccines tested in the 1960's led to vaccine-enhanced disease upon viral challenge, which has undermined RSV vaccin...

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Autors principals: Lindell, Dennis M., Morris, Susan B., White, Maria P., Kallal, Lara E., Lundy, Phillip K., Hamouda, Tarek, Baker, James R., Lukacs, Nicholas W.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137595/
https://ncbi.nlm.nih.gov/pubmed/21789184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021823
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