Cyclosporine A, FK506, and NIM811 ameliorate prolonged CBF reduction and impaired neurovascular coupling after cortical spreading depression

Cortical spreading depression (CSD) is associated with mitochondrial depolarization, increasing intracellular Ca(2+), and the release of free fatty acids, which favor opening of the mitochondrial permeability transition pore (mPTP) and activation of calcineurin (CaN). Here, we test the hypothesis th...

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Bibliografiske detaljer
Main Authors: Piilgaard, Henning, Witgen, Brent M, Rasmussen, Peter, Lauritzen, Martin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137467/
https://ncbi.nlm.nih.gov/pubmed/21427730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.28
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