False positive peaks in ChIP-seq and other sequencing-based functional assays caused by unannotated high copy number regions

Motivation: Sequencing-based assays such as ChIP-seq, DNase-seq and MNase-seq have become important tools for genome annotation. In these assays, short sequence reads enriched for loci of interest are mapped to a reference genome to determine their origin. Here, we consider whether false positive pe...

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Bibliographic Details
Main Authors: Pickrell, Joseph K., Gaffney, Daniel J., Gilad, Yoav, Pritchard, Jonathan K.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137225/
https://ncbi.nlm.nih.gov/pubmed/21690102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btr354
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