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mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets

Protein kinase B (PKB, Akt) is a Ser/Thr kinase involved in the regulation of cell survival, proliferation, and metabolism and is activated by dual phosphorylation on Thr(308) in the activation loop and Ser(473) in the hydrophobic motif. It plays a contributory role to platelet function, although li...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Moore, Samantha F., Hunter, Roger W., Hers, Ingeborg
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137030/
https://ncbi.nlm.nih.gov/pubmed/21592956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.202341
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