Overexpression of Human and Fly Frataxins in Drosophila Provokes Deleterious Effects at Biochemical, Physiological and Developmental Levels

BACKGROUND: Friedreich's ataxia (FA), the most frequent form of inherited ataxias in the Caucasian population, is caused by a reduced expression of frataxin, a highly conserved protein. Model organisms have contributed greatly in the efforts to decipher the function of frataxin; however, the pr...

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Detalhes bibliográficos
Main Authors: Navarro, Juan A., Llorens, José V., Soriano, Sirena, Botella, José A., Schneuwly, Stephan, Martínez-Sebastián, María J., Moltó, María D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136927/
https://ncbi.nlm.nih.gov/pubmed/21779322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021017
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