Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics

BACKGROUND: The development of plasma biomarkers could facilitate early detection, risk assessment and therapeutic monitoring in Alzheimer's disease (AD). Alterations in ceramides and sphingomyelins have been postulated to play a role in amyloidogensis and inflammatory stress related neuronal a...

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Detalhes bibliográficos
Main Authors: Han, Xianlin, Rozen, Steve, Boyle, Stephen H., Hellegers, Caroline, Cheng, Hua, Burke, James R., Welsh-Bohmer, Kathleen A., Doraiswamy, P. Murali, Kaddurah-Daouk, Rima
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136924/
https://ncbi.nlm.nih.gov/pubmed/21779331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021643
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