Protective Immunity Induced with the RTS,S/AS Vaccine Is Associated with IL-2 and TNF-α Producing Effector and Central Memory CD4(+) T Cells

A phase 2a RTS,S/AS malaria vaccine trial, conducted previously at the Walter Reed Army Institute of Research, conferred sterile immunity against a primary challenge with infectious sporozoites in 40% of the 80 subjects enrolled in the study. The frequency of Plasmodium falciparum circumsporozoite p...

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Détails bibliographiques
Auteurs principaux: Lumsden, Joanne M., Schwenk, Robert J., Rein, Lisa E., Moris, Philippe, Janssens, Michel, Ofori-Anyinam, Opokua, Cohen, Joe, Kester, Kent E., Heppner, D. Gray, Krzych, Urszula
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136919/
https://ncbi.nlm.nih.gov/pubmed/21779319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020775
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