Activation of Akt by the Bacterial Inositol Phosphatase, SopB, is Wortmannin Insensitive

Salmonella enterica uses effector proteins translocated by a Type III Secretion System to invade epithelial cells. One of the invasion-associated effectors, SopB, is an inositol phosphatase that mediates sustained activation of the pro-survival kinase Akt in infected cells. Canonical activation of A...

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Autores principales: Cooper, Kendal G., Winfree, Seth, Malik-Kale, Preeti, Jolly, Carrie, Ireland, Robin, Knodler, Leigh A., Steele-Mortimer, Olivia
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136525/
https://ncbi.nlm.nih.gov/pubmed/21779406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022260
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