CD103 Deficiency Prevents Graft-versus-Host Disease but Spares Graft-versus-Tumor Effects Mediated by Alloreactive CD8 T Cells

BACKGROUND: Graft-versus-host disease (GVHD) remains the main barrier to broader application of allogeneic hematopoietic stem cell transplantation (alloSCT) as a curative therapy for host malignancy. GVHD is mediated by allogeneic T cells directed against histocompatibility antigens expressed by hos...

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Main Authors: Liu, Kechang, Anthony, Bryan A., Yearsly, Martha M., Hamadani, Mehdi, Gaughan, Alice, Wang, Jiao-Jing, Devine, Steven M., Hadley, Gregg A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136479/
https://ncbi.nlm.nih.gov/pubmed/21779359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021968
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