Rotavirus Stimulates Release of Serotonin (5-HT) from Human Enterochromaffin Cells and Activates Brain Structures Involved in Nausea and Vomiting

Rotavirus (RV) is the major cause of severe gastroenteritis in young children. A virus-encoded enterotoxin, NSP4 is proposed to play a major role in causing RV diarrhoea but how RV can induce emesis, a hallmark of the illness, remains unresolved. In this study we have addressed the hypothesis that R...

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Autors principals: Hagbom, Marie, Istrate, Claudia, Engblom, David, Karlsson, Thommie, Rodriguez-Diaz, Jesus, Buesa, Javier, Taylor, John A., Loitto, Vesa-Matti, Magnusson, Karl-Eric, Ahlman, Håkan, Lundgren, Ove, Svensson, Lennart
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136449/
https://ncbi.nlm.nih.gov/pubmed/21779163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002115
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