The transcription factor PU.1 is required for the development of interleukin 9-producing T cells and allergic inflammation

CD4(+) T helper cells acquire effector phenotypes that promote specialized inflammatory responses. We show that the ETS family transcription factor, PU.1 was required for the development of an interleukin 9 (IL-9)-secreting subset of T(H) cells. Decreasing PU.1 expression either by conditional delet...

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Autors principals: Chang, Hua-Chen, Sehra, Sarita, Goswami, Ritobrata, Yao, Weiguo, Yu, Qing, Stritesky, Gretta L., Jabeen, Rukhsana, McKinley, Carl, Ahyi, Ayele-Nati, Han, Ling, Nguyen, Evelyn T., Robertson, Michael J., Perumal, Narayanan B., Tepper, Robert S., Nutt, Stephen L., Kaplan, Mark H.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136246/
https://ncbi.nlm.nih.gov/pubmed/20431622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1867
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