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TNF signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death but not tuberculous granuloma formation
Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granulomas, organized aggregates of macrophages and other immune cells. Loss of TNF signaling causes progression of tuberculosis in humans and the increased mortality of...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3136176/ https://ncbi.nlm.nih.gov/pubmed/18691913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.06.011 |
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