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Semitelechelic HPMA Copolymers Functionalized with Triphenylphosphonium as Drug Carriers for Membrane Transduction and Mitochondrial Localization

Semitelechelic HPMA (N-(2-hydroxypropyl)methacrylamide) copolymers possessing a single terminal lipophilic triphenylphosphonium (TPP) cation and fluorescent labels were synthesized to determine how the attached cation affected cellular uptake and intracellular trafficking. In vitro mitochondrial upt...

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Détails bibliographiques
Auteurs principaux: Callahan, Jon, Kopeček, Jindřich
Format: Artigo
Langue:Inglês
Publié: 2006
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136128/
https://ncbi.nlm.nih.gov/pubmed/16903681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm060336m
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