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THE MOUSE RANKL GENE LOCUS IS DEFINED BY A BROAD PATTERN OF HISTONE ACETYLATION AND REGULATED THROUGH DISTINCT DISTAL ENHANCERS
RANKL is a stromal cell-derived tumor necrosis factor (TNF)-like factor that plays a primary role in osteoclast formation and function. Recent studies suggest that 1,25(OH)(2)D(3) induces Rankl expression via vitamin D receptor (VDR) interaction at several enhancers located up to 76 kb upstream of t...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3135786/ https://ncbi.nlm.nih.gov/pubmed/21465526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.23123 |
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