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THE MOUSE RANKL GENE LOCUS IS DEFINED BY A BROAD PATTERN OF HISTONE ACETYLATION AND REGULATED THROUGH DISTINCT DISTAL ENHANCERS

RANKL is a stromal cell-derived tumor necrosis factor (TNF)-like factor that plays a primary role in osteoclast formation and function. Recent studies suggest that 1,25(OH)(2)D(3) induces Rankl expression via vitamin D receptor (VDR) interaction at several enhancers located up to 76 kb upstream of t...

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Main Authors: Martowicz, Melissa L., Meyer, Mark B., Pike, J. Wesley
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135786/
https://ncbi.nlm.nih.gov/pubmed/21465526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.23123
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