Murine monoclonal antibodies to Klebsiella pneumoniae protect against lethal endotoxemia and experimental infection with capsulated K. pneumoniae.

To prepare monoclonal antibodies (MAbs) directed against the core-lipid A fractions of smooth lipopoly-saccharide (LPS) from Klebsiella pneumoniae O1:K2, we immunized BALB/c mice with the LPS-associated proteins plus LPS. This preparation exposed the core-lipid A moiety, which is normally hidden in...

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Vydáno v:Infect Immun
Hlavní autoři: Mandine, E, Salles, M F, Zalisz, R, Guenounou, M, Smets, P
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 1990
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC313574/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1696932/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.58.9.2828-2833.1990
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