Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing

Mammals lacking BLOC-3 have impaired formation of melanosomes, a type of lysosome-related organelle (LRO), and, in earlier work, we found that a subunit of the BLOC-3 complex inhibits loading of Argonaute (Ago) proteins with small ribonucleic acids (RNAs) in Drosophila melanogaster cells. Small RNAs...

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Detalhes bibliográficos
Main Authors: Harris, Dinari A., Kim, Kevin, Nakahara, Kenji, Vásquez-Doorman, Constanza, Carthew, Richard W.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135410/
https://ncbi.nlm.nih.gov/pubmed/21746852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201102021
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