Cellular Functions of Ufd2 and Ufd3 in Proteasomal Protein Degradation Depend on Cdc48 Binding

The chaperone-related AAA ATPase Cdc48 (p97/VCP in higher eukaryotes) segregates ubiquitylated proteins for subsequent degradation by the 26S proteasome or for nonproteolytic fates. The specific outcome of Cdc48 activity is controlled by the evolutionary conserved cofactors Ufd2 and Ufd3, which anta...

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Hauptverfasser: Böhm, Stefanie, Lamberti, Giorgia, Fernández-Sáiz, Vanesa, Stapf, Christopher, Buchberger, Alexander
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135295/
https://ncbi.nlm.nih.gov/pubmed/21282470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00962-10
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