Electrophilic PPARγ Ligands Attenuate IL-1β and Silica-Induced Inflammatory Mediator Production in Human Lung Fibroblasts via a PPARγ-Independent Mechanism

Acute and chronic lung inflammation is associated with numerous important disease pathologies including asthma, chronic obstructive pulmonary disease and silicosis. Lung fibroblasts are a novel and important target of anti-inflammatory therapy, as they orchestrate, respond to, and amplify inflammato...

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Main Authors: Hogan, Christopher M., Thatcher, Thomas H., Sapinoro, Ramil E., Gurell, Michael N., Ferguson, Heather E., Pollock, Stephen J., Jones, Carolyn, Phipps, Richard P., Sime, Patricia J.
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135061/
https://ncbi.nlm.nih.gov/pubmed/21765824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/318134
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