The Use of Radioactive Marker as a Tool to Evaluate the Drug Release in Plasma and Particle Biodistribution of Block Copolymer Nanoparticles

Diblock copolymer nanoparticles encapsulating a paclitaxel prodrug, Propac 7, have been used to demonstrate the usefulness of a nonmetabolizable radioactive marker, cholesteryl hexadecyl ether (CHE), to evaluate nanoparticle formulation variables. Since CHE did not exchange out of the nanoparticles,...

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Bibliografiske detaljer
Main Authors: Johnstone, Sharon, Ansell, Steven, Xie, Sherwin, Mayer, Lawrence, Tardi, Paul
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134861/
https://ncbi.nlm.nih.gov/pubmed/21773044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/349206
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