C-Terminal Domain Deletion Enhances the Protective Activity of cpa/cpb Loaded Solid Lipid Nanoparticles against Leishmania major in BALB/c Mice

BACKGROUND: We have demonstrated that vaccination with pDNA encoding cysteine proteinase Type II (CPA) and Type I (CPB) with its unusual C-terminal extension (CTE) can partially protect BALB/c mice against cutaneous leishmanial infection. Unfortunately, this protection is insufficient to completely...

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Detalhes bibliográficos
Main Authors: Doroud, Delaram, Zahedifard, Farnaz, Vatanara, Alireza, Taslimi, Yasaman, Vahabpour, Rouholah, Torkashvand, Fatemeh, Vaziri, Behrooz, Rouholamini Najafabadi, Abdolhossein, Rafati, Sima
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134432/
https://ncbi.nlm.nih.gov/pubmed/21765963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001236
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